Environmental Enteropathy, Oral Vaccine Failure and Growth Faltering in Infants in Bangladesh

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Environmental Enteropathy, Oral Vaccine Failure and Growth Faltering in Infants in Bangladesh

BACKGROUND Environmental enteropathy (EE) is a subclinical enteric condition found in low-income countries that is characterized by intestinal inflammation, reduced intestinal absorption, and gut barrier dysfunction. We aimed to assess if EE impairs the success of oral polio and rotavirus vaccines in infants in Bangladesh. METHODS We conducted a prospective observational study of 700 infants ...

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We assessed the relationship of fecal environmental contamination and environmental enteropathy. We compared markers of environmental enteropathy, parasite burden, and growth in 119 Bangladeshi children (≤ 48 months of age) across rural Bangladesh living in different levels of household environmental cleanliness defined by objective indicators of water quality and sanitary and hand-washing infr...

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BACKGROUND Growth faltering in West African children has previously been associated with dietary exposure to aflatoxins, particularly upon weaning. However, in animal studies in utero exposure to low levels of aflatoxin also results in growth faltering. OBJECTIVE This study investigated the effect of in utero aflatoxin exposure on infant growth in the first year of life in The Gambia. METHO...

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Household Environmental Conditions Are Associated with Enteropathy and Impaired Growth in Rural Bangladesh

We assessed the relationship of fecal environmental contamination and environmental enteropathy. We compared markers of environmental enteropathy, parasite burden, and growth in 119 Bangladeshi children (≤ 48 months of age) across rural Bangladesh living in different levels of household environmental cleanliness defined by objective indicators of water quality and sanitary and hand-washing infr...

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Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response.

Environmental enteropathy (EE) is a poorly defined state of intestinal inflammation without overt diarrhoea that occurs in individuals exposed over time to poor sanitation and hygiene. It is characterized pathologically by small intestine villous blunting and inflammation. In children from low-income countries, it is implicated as a cause of malnutrition, oral vaccine failure and impaired cogni...

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ژورنال

عنوان ژورنال: EBioMedicine

سال: 2015

ISSN: 2352-3964

DOI: 10.1016/j.ebiom.2015.09.036